The procurement brings the total amount of doses secured from the US and German drugmakers to 44.8 million, enough to cover 70% of Malaysia's population, Khairy said.
AstraZeneca's French-Australian boss Pascal Soriot has argued that his company's contract with the EU binds it only to a "best reasonable efforts" clause.
Maria Jesus Montero said the total was equivalent to twice the target population in Spain, where around 8.1 million people have already received a full course of vaccines.
The vaccine will be exported to neighboring countries in South America, since Brazil has not yet approved the Russian shot for domestic use.
The factory's first batch of 100,000 doses were packed into boxes labeled in Spanish, although the countries receiving them have not been decided yet by the Russian Direct Investment Fund (RDIF), executives said.
The contract reserves the doses on behalf of all European Union member states, between end 2021 to 2023, the statement added. The contract requires that the vaccine production is based in the EU and that essential components are sourced from the EU.
PM Imran Khan and Chinese PM Li Keqiang held a telephonic conversation on the occasion of the 70th anniversary of the establishment of Pakistan-China diplomatic ties.
PM Khan thanked his counterpart for providing assistance to the National Institute of Health for establishing a vaccine manufacturing facility in Pakistan.
"Ecuador joins a number of other nations of South America which have included Sputnik V in their coronavirus vaccine portfolios," Kirill Dmitriev, the head of RDIF, said in a statement.
The WHO is hoping more countries will follow France and Sweden in donating shots to COVAX after inoculating their priority populations to help address a gulf in vaccination rates.