Luis Muriel scored a consolation goal for Atalanta just before Asensio added the third to confirm Madrid's presence in the draw for the last eight on March 19.
The Belgian international joined Real in a 150 million euro ($178.83 million) deal in 2019 but has been blighted by injuries, making 25 La Liga appearances since signing.
"He won't be fit. They're things that I can't explain. I want to be positive and hope that it's not too much of a problem," Zidane told a news conference.
No English club has ever won both domestic cup competitions, the league and European Cup in the same season but City remain in the mix for all of them.
"Four titles has never happened before and I don't think it will happen this season with the situation," said Guardiola.
Juventus were knocked out in the last 16 of the Champions League on Tuesday as 10-man Porto progressed on away goals following a 4-4 aggregate draw.
The Italians' defeat sparked criticism of 36-year-old Ronaldo in the media, with the front page of Wednesday's Corriere dello Sport saying "Betrayed by Ronaldo".
Ronaldo was criticised for a disappointing performance after the Serie A champions were eliminated by the Portuguese side on away goals, their second consecutive last 16 exit in the competition.
"It's normal that he's disappointed by what happened the other night, like the rest of the team," Pirlo told a news conference.
The jury is still out on rookie coach Andrea Pirlo, with Juve also 10 points behind leaders Inter Milan in the Serie A title race ahead of Sunday's trip to Cagliari.
They do have a game in hand on Inter, which is against Napoli next Wednesday, and nothing other than two victories in those matches will do following Tuesday's disappointing showing against 10-man Porto.
Lionel Messi scored a stunning equaliser to make it 1-1 on the night in Paris, but his penalty was saved on the stroke of halftime with the scores level, meaning what could have been a blockbuster second half turned into a non-event.
More than the number of misses, it is perhaps the size of the games that they occur in that sets alarm bells ringing.
The European Leagues held an online meeting with clubs and leagues from across the continent on Wednesday to discuss UEFA's plans for a reformed and expanded Champions League.
I think if there is anybody or (any) clubs trying to organise a Super League they should be thrown out of association football, that for me is a different solution to that matter.
Conceicao was part of the last Porto side to win the Champions League in 2004 under Jose Mourinho and masterminded their most significant win in the competition since then.
The feat came 17 years to the day when Porto knocked out Manchester United and Mourinho announced himself to the world with his iconic celebration on the Old Trafford touchline.
Strikers Yussuf Poulsen and Alexander Sorloth have been in superb form in recent weeks along with Christopher Nkunku, and Leipzig have won seven of their last eight Bundesliga games.
"I am happy that our attack in the past months has had a big influence in our wins," Nagelsmann told.
Webo, a former Cameroon international, said Coltescu had disrespected him by referring to him as "the Black one" and an investigation was launched by European soccer's governing body.
Assistant referee Octavian Sovre was also reprimanded for his role and ordered to attend an educational programme before June 30.
UEFA has proposed a major change to the Champions League from 2024 with 36 rather than 32 teams and an overhaul of the group stage into a single table rather than the current groups of four clubs.
UEFA's initial proposal allowed for extra spots to be given for teams placed highest in their rankings, opening the way for the top leagues to have more than four clubs on a regular basis.
Chelsea beat champions Liverpool 1-0 on Thursday to climb to fourth in the table, a prospect that looked bleak when Lampard was dismissed with the team in ninth place.
"It's proven that Chelsea is an organisation and a club that has everything that you need to be successful as a coach and as a football team, so now it's my job to bring out the very best of myself, together with the team.
Atletico have been the best side in Spain all season but against a Chelsea side still learning the ropes under Thomas Tuchel, they were utterly toothless and failed to have a shot on target.
"This is a big reflection how poor La Liga is at the moment," said 2008 Champions League winner Rio Ferdinand on BT Sport.
Bayern have won six titles in the past nine months but have stumbled in their last two league matches with a 3-3 draw against visiting Arminia Bielefeld and a 2-1 defeat on Saturday by Eintracht Frankfurt.
"We know what has happened in the past days," Flick said on the two matches last week. "Against Lazio I want us to be there as a team from the start.
We are in a good flow. We have won the last four matches while Liverpool have not won five out of their last seven.
They are the slight favourites based on their international experience but we have shown that we can hold our own against such teams, both last year and this season with a very tough group stage.
Governing body had banned City from European competition for two years after ruling they had breached Financial Fair Play (FFP) regulations but City won an appeal last month to have that verdict and sanction overturned.